Chapter 16: The Molecular Basis of Inheritance
 
Chapter Quiz
 

Chapter Quiz


1 .       During Griffith's experiments with Streptococcus pneumoniae in mice, material from _____ bacteria transformed _____ bacteria. (Concept 16.1E-Book) [Hint]

 living nonvirulent ... living virulent
 living nonvirulent ... heat-killed virulent
 living virulent ... heat-killed nonvirulent
 heat-killed virulent ... living nonvirulent
 heat-killed nonvirulent ... living virulent


2 .       Avery and his colleagues' 1944 experiment showed that DNA _____. (Concept 16.1E-Book) [Hint]

 was the substance that transformed the bacteria in Griffith's experiment
 consists of sugars, phosphate groups, and bases
 has two strands held together with hydrogen bonds
 uses three bases to code for one amino acid
 contains adenine, guanine, thymine, and cytosine


3 .       A scientist assembles a bacteriophage with the protein coat of phage T2 and the DNA of phage T4. If this composite phage were allowed to infect a bacterium, the phages produced in the host cell would have _____. (Concept 16.1E-Book) [Hint]

 the protein of T2 and the DNA of T4
 the protein of T4 and the DNA of T2
 a mixture of the DNA and proteins of both phages
 the protein and DNA of T2
 the protein and DNA of T4


4 .       In an important experiment, a radioactively labeled bacteriophage was allowed to infect bacteria. In a first trial, the phage contained radioactive DNA, and radioactivity was detected inside the bacteria. Next, phage containing radioactive protein was used, and the radioactivity was not detected inside the bacteria. These experiments led to the conclusion that _____. (Concept 16.1E-Book) [Hint]

 the genetic material of the phage is DNA
 bacteriophages can infect bacteria
 DNA is made of nucleotides
 the genetic material of the phage is protein
 genes are on chromosomes


5 .       Monomers for the synthesis of DNA are called _____. (Concept 16.1E-Book) [Hint]

 amino acids
 fatty acids
 nucleotides
 monosaccharides
 disaccharides


6 .       Which one of the following is not true about double-stranded DNA? (Concept 16.1E-Book) [Hint]

 It is helical.
 It contains phosphodiester linkages.
 The two strands are complementary.
 Adenine and uracil are present in equal amounts.
 The strands run antiparallel.


7 .       Chargaff found that for DNA _____. (Concept 16.1E-Book) [Hint]

 the ratio of A to C is close to 1:1 and the ratio of G to T is close to 1:1
 the ratio of A to T is close to 1:1 and the ratio of G to C is close to 1:1
 the ratio of A to G is close to 1:1 and the ratio of T to C is close to 1:1
 A + T = G + C
 A + T = 50% of the total bases


8 .       What technique was most helpful to Watson and Crick in developing their model for the structure of DNA? (Concept 16.1E-Book) [Hint]

 radioactive labeling
 X-ray crystallography
 electrophoresis
 cloned DNA
 transgenic animals


9 .       In DNA, the two purines are _____, and the two pyrimidines are _____. (Concept 16.1E-Book) [Hint]

 cytosine and guanine ... adenine and thymine
 cytosine and thymine ... adenine and guanine
 adenine and guanine ... cytosine and thymine
 adenine and thymine ... cytosine and guanine
 adenine and cytosine ... guanine and thymine


10 .       Which of the following is correct? (Concept 16.1E-Book) [Hint]

 Adenine forms two hydrogen bonds with guanine; thymine forms three hydrogen bonds with cytosine.
 Adenine forms three hydrogen bonds with thymine; guanine forms two hydrogen bonds with cytosine.
 Adenine forms two covalent bonds with thymine; guanine forms three covalent bonds with cytosine.
 Adenine forms two hydrogen bonds with thymine; guanine forms three hydrogen bonds with cytosine.
 Adenine forms three covalent bonds with thymine; guanine forms two covalent bonds with cytosine.


11 .       The two sugar-phosphate strands of a DNA molecule are joined to each other through _____. (Concept 16.1E-Book) [Hint]

 5' deoxyribose and phosphate bonds
 hydrogen bonds between nucleotide bases
 covalent bonds between nitrogen atoms in adenine and in thymine
 covalent bonds between carbon atoms in deoxyribose molecules
 ionic bonds between guanine and cytosine


12 .       The information in DNA is contained in _____. (Concept 16.1E-Book) [Hint]

 the variation in the structure of nucleotides that make up the DNA molecule
 the types of sugars used in making the DNA molecule
 the sequence of amino acids that make up the DNA molecule
 the sequence of nucleotides along the length of the two strands of the DNA molecule
 all of the above


13 .       Who is credited with discovering the structure of the DNA double helix? (Concept 16.1E-Book) [Hint]

 Jacob and Monod
 Watson and Crick
 Avery, McCarty, and MacLeod
 Griffith
 Hershey and Chase


14 .       During the replication of DNA, _____. (Concept 16.2E-Book) [Hint]

 both strands of a molecule act as templates
 the reaction is catalyzed by RNA polymerase
 errors never occur
 only one strand of the molecule acts as a template
 the cell undergoes mitosis


15 .       The experiments of Meselson and Stahl showed that DNA _____. (Concept 16.2E-Book) [Hint]

 is the genetic material
 replicates in a semiconservative fashion
 contains complementary base pairing
 codes for the sequence of amino acids in proteins
 is composed of nucleotides


16 .       The DNA structures of prokaryotes and eukaryotes are different in several ways, but one way in which they are the same is that _____. (Concept 16.2E-Book) [Hint]

 both have a sugar-phosphate backbone
 histones are present in the nucleosomes
 the DNA is packaged into several linear chromosomes
 most of the DNA is in the form of plasmids
 both have a single circular chromosome


17 .       Which of the following statements about replication origins is incorrect? (Concept 16.2E-Book) [Hint]

 Bacterial chromosomes have a single origin, but eukaryotic chromosomes have many origins.
 In bacteria, the DNA sequence at the origin is recognized by specific proteins that then bind to the origin.
 The two strands of DNA at the origin are separated, allowing the formation of a replication bubble.
 In both prokaryotes and eukaryotes, replication proceeds in both directions from each origin.
 None of the above.


18 .       At each end of a DNA replication bubble is _____. (Concept 16.2E-Book) [Hint]

 an origin of replication
 a gene
 a telomere
 a replication fork
 a ribosome


19 .       The role of DNA polymerases in DNA replication is to _____. (Concept 16.2E-Book) [Hint]

 attach free nucleotides to the new strand
 synthesize an RNA primer to initiate DNA strand synthesis
 link together short strands of DNA
 separate the two strands of DNA
 all of the above


20 .       The rate of elongation in prokaryotes is _____ the rate in eukaryotes. (Concept 16.2E-Book) [Hint]

 much slower than
 at about the same speed as
 much faster than
 sometimes faster and sometimes slower than
 The rates are not comparable, since elongation only occurs in prokaryotes.


21 .       The two strands of a DNA double helix are antiparallel. This means that _____. (Concept 16.2E-Book) [Hint]

 the two strands are mirror images
 only one of the two strands can be used as a template for replication, because DNA polymerase only works in one direction
 one strand is actually composed of RNA
 one strand runs in the 5' to 3' direction, and the other runs in the 3' to 5' direction
 they both run in the 3' to 5' direction


22 .       One strand of a DNA molecule has the base sequence 5'-ATAGGT-3'. The complementary base sequence on the other strand of DNA will be 3'-_______-5'. (Concept 16.2E-Book) [Hint]

 TATCCA
 TGGATA
 TGGAUA
 UAUCCA
 ATAGGT


23 .       DNA polymerase adds nucleotides to the _____ of the leading strands, and to the _____ of the lagging strands (Okazaki fragments). (Concept 16.2E-Book) [Hint]

 5' end ... 3' end
 3' end ... 5' end
 5' end ... 5' end
 3' end ... 3' end
 sugar group ... phosphate group


24 .       What enzyme joins Okazaki fragments? (Concept 16.2E-Book) [Hint]

 DNA polymerase
 DNA ligase
 topoisomerase
 helicase
 primase


25 .       After the formation of a replication bubble, which of the following is the correct sequence of enzymes used for the synthesis of the lagging DNA strand? (Concept 16.2E-Book) [Hint]

 primase, helicases, DNA polymerase, ligase
 helicases, primase, ligase, DNA polymerase
 helicases, primase, DNA polymerase, ligase
 helicases, DNA polymerase, primase, ligase
 ligase, primase, DNA polymerase, helicases


26 .       Which of the following components is (are) required for DNA replication? (Concept 16.2E-Book) [Hint]

 ribosomes
 transfer RNA
 RNA primer
 RNA polymerase
 all of the above


27 .       The removal of the RNA primer and addition of DNA nucleotides to the 3' end of Okazaki fragments in its place is carried out by _____. (Concept 16.1E-Book) [Hint]

 nuclease
 primase
 DNA polymerase I
 DNA polymerase III
 ligase


28 .       The unwinding of DNA at the replication fork causes twisting and strain in the DNA ahead of the fork, which is relieved by an enzyme called _____. (Concept 16.2E-Book) [Hint]

 relievase
 primase
 ligase
 topoisomerase
 ribosomes


29 .       Once the DNA at the replication fork is unwound by helicases, what prevents the two strands from coming back together to reform a double helix? (Concept 16.2E-Book) [Hint]

 The helicase modifies the DNA in such a way as to eliminate the affinity between the two strands.
 DNA polymerase follows the helicase so closely that there is no chance for the strands to come back together.
 Single-strand binding proteins bind the unwound DNA and prevent the double helix from reforming.
 The helicase pushes the two strands so far apart that they have no chance of finding each other.
 One of the strands is rapidly degraded, preventing the double helix from reforming.


30 .       Which description of DNA replication is correct? (Concept 16.2E-Book) [Hint]

 Helicases separate the two strands of the double helix, and DNA polymerases then construct two new strands using each of the original strands as templates.
 Ligase assembles single-stranded codons, then polymerase knits these codons together into a DNA strand.
 The two strands of DNA separate, and restriction enzymes cut up one strand. Then polymerase synthesizes two new strands out of the old ones.
 The two strands separate, and each one receives a complementary strand of RNA. Then this RNA serves as a template for the assembly of many new strands of DNA.
 Ligase separates the two strands of the DNA double helix. Then DNA polymerase synthesizes the leading strand and primase synthesizes the lagging strand.


31 .       The text describes reasons why it is not accurate to compare DNA replication by polymerases to a locomotive moving down the track. Which of the statements below is not a proper explanation of why this comparison is inaccurate? (Concept 16.2E-Book) [Hint]

 Instead of moving along the DNA, the DNA polymerase "reels in" the DNA much like a sewing machine pulls material toward its needle.
 The replication machinery is far more complex than a train on a track.
 More than one train can be on the same track, but only one DNA polymerase can be on a given chromosome at any given time.
 All of the above.
 None of the above.


32 .       The overall error rate in the completed DNA molecule is approximately _____. (Concept 16.2E-Book) [Hint]

 1 error per 100 nucleotides
 1 error per 1,000 nucleotides
 1 error per 1,000,000 nucleotides
 1 error per 1,000,000,000 nucleotides
 1 per 10,000,000,000 nucleotides


33 .       The incorporation of an incorrect base into the DNA during replication _____. (Concept 16.2E-Book) [Hint]

 will almost certainly lead to the death of the cell
 cannot be repaired, and a new mutation will invariably result
 will trigger the cell to destroy the new strand, and replication will begin again
 can be repaired by the mismatch repair system
 is virtually impossible, as the accuracy of DNA polymerase is such that errors almost never occur


34 .       Which of the following enzymes is not involved in nucleotide excision repair? (Concept 16.2E-Book) [Hint]

 nuclease
 DNA polymerase
 ligase
 primase


35 .       Individuals with the disorder xeroderma pigmentosum _____. (Concept 16.2E-Book) [Hint]

 are hypersensitive to sunlight
 have high rates of skin cancer
 often have inherited defects in the nucleotide excision repair system
 have difficulty repairing thymine dimmers
 all of the above


36 .       Unlike prokaryotic DNA replication, replication of eukaryotic chromosomes _____. (Concept 16.2E-Book) [Hint]

 involves two leading strands and no lagging strands
 cannot be completed by DNA polymerase
 is semiconservative
 has a single origin
 is error free


37 .       Telomeres _____. (Concept 16.2E-Book) [Hint]

 get longer with continued cell division
 are found in both prokaryotic and eukaryotic cells
 remain the same regardless of the frequency of cell division
 get shorter with continued cell division
 are shorter for younger individuals


38 .       Telomerase _____. (Concept 16.2E-Book) [Hint]

 is an enzyme made up of protein and RNA that lengthens telomeres
 prevents the loss of centromeric DNA
 speeds cell aging
 slows the rate of cancer cell growth
 splits telomeres







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