Chapter 21: The Genetic Basis of Development
 
Chapter Quiz
 

Chapter Quiz


1 .       A model organism for genetic studies of development should ideally _____. (OverviewE-Book) [Hint]

 be similar in significant ways to a larger group of animals and most preferably to humans.
 have a short generation time.
 have a relatively small genome.
 be well characterized in terms of its genes and overall development.
 all of the above


2 .       The process by which cells become specialized is called _____. (Concept 21.1E-Book) [Hint]

 apoptosis
 totipotency
 divergence
 differentiation
 morphogenesis


3 .       _____ ensures that enough cells are present to support development, and _____ ensures that the developing organism is not simply a formless ball of cells. (Concept 21.1E-Book) [Hint]

 Cell division ... morphogenesis
 Morphogenesis ... differentiation
 Differentiation ... morphogenesis
 Cell division ... determination
 Determination ... differentiation


4 .       Embryonic tissue that persists in the adult plant is called _____. (Concept 21.1E-Book) [Hint]

 sclerenchyma
 mesophyll
 collenchyma
 meristem
 parenchyma


5 .       Your muscle and bone cells are different because _____. (Concept 21.2E-Book) [Hint]

 they contain different sets of genes
 they are differentiated
 they contain different operons
 different genes are switched on and off in each type of cell
 they contain different histones


6 .       In frogs, when an intestinal cell of a tadpole is transferred into an egg whose nucleus has been removed (nuclear transplantation), some of the eggs will develop into normal tadpoles. This demonstrates _____. (Concept 21.2E-Book) [Hint]

 that frogs have meristematic cells
 that intestinal cells are not differentiated
 genomic equivalence
 that frogs have large eggs
 that these cells could not dedifferentiate


7 .       A mature cell of a mature plant can often develop into a new adult. This demonstrates that these plant cells are _____. (Concept 21.2E-Book) [Hint]

 zygotic
 differentiated
 induced
 anucleate
 totipotent


8 .       The alterations in gene expression that accompany cell differentiation involve all of the following mechanisms except _____. (Concept 21.2E-Book) [Hint]

 alterations in chromatin structure
 the presence of cell-type-specific transcription factors
 DNA methylation
 histone modifications
 elimination of unused genes from the genome


9 .       In the case of Dolly (the clone), a nucleus from a mammary gland cell of one sheep was put into the enucleated ovum of another sheep, and this cell was then implanted in the uterus of a third sheep. If you consider only the generation that directly preceded Dolly, how many genetic parents does she have? (Concept 21.2E-Book) [Hint]

 one
 two
 three
 four
 five


10 .       The efficiency of cloning, and the ability to generate healthy cloned animals, has been largely hampered by the difficulty of _____. (Concept 21.2E-Book) [Hint]

 completely reversing epigenetic alterations in donor cell nuclei such as DNA methylation and chromatin packing
 inducing recombination in differentiated donor cells in order to restore the full genomic complement
 transforming donor cells with genes encoding proteins required for normal embryonic development
 physically removing the nucleus from the egg cell that will ultimately receive the donor cell nucleus
 implanting the clone into the surrogate mother


11 .       Cells that are capable of developing into multiple, but not all, cell types are called _____. (Concept 21.2E-Book) [Hint]

 differentiated
 totipotent
 blastocysts
 genomically equivalent
 pluripotent


12 .       "Therapeutic cloning" refers to _____. (Concept 21.2E-Book) [Hint]

 the use of cloned embryos as a source of stem cells that could be used to treat disease
 treating patients with therapeutic proteins made using recombinant DNA technology
 cloning animals to obtain organs that could be used for transplantation into humans
 treating a genetic disease by obtaining cells from an individual with the disease, introducing genes into the cells in order to repair the genetic defect, and then reintroducing the cells back into the individual
 all of the above


13 .       Differentiation _____. (Concept 21.2E-Book) [Hint]

 requires apoptosis
 precedes determination
 requires transcription of the ced-9 gene
 does not occur in plants
 requires the transcription of tissue-specific genes


14 .       Specific cells that appear undifferentiated under the microscope but are already fated to become muscle cells are called _____. (Concept 21.2E-Book) [Hint]

 meristematic cells
 bicoids
 myocytes
 muscle cells
 myoblasts


15 .       MyoD promotes muscle cell development by _____. (Concept 21.2E-Book) [Hint]

 turning on the expression of multiple muscle-related genes.
 stimulating a receptor on the surface of muscle cells, thus activating a signal-transduction pathway that promotes muscle development.
 increasing the translation of muscle-related genes.
 stimulating the production of muscle-specific splicing variants of certain mRNAs.
 enhancing apoptosis of non-muscle cells.


16 .       Which of the following has the earliest influence on development? (Concept 21.3E-Book) [Hint]

 homeotic genes
 segmentation genes
 induction
 cytoplasmic determinants
 pair-rule genes


17 .       Cytoplasmic determinants _____. (Concept 21.3E-Book) [Hint]

 are coded for by maternal genes
 act by binding to a plasma protein receptor that then initiates a signal-transduction pathway
 are coded for by paternal genes
 are carried to the ovum by the sperm
 are coded for by embryonic genes


18 .       Cells can influence each other's development by a process known as _____. (Concept 21.2E-Book) [Hint]

 fating
 chimeras
 induction
 cleavage
 apoptosis


19 .       In contrast to the vertebrate blastula, the fruit fly blastula _____. (Concept 21.3E-Book) [Hint]

 has differentiated cells
 is multinucleate
 consists of totipotent cells
 has cells that are genomic equivalents
 does not exhibit concentration gradients of cytoplasmic determinants


20 .       Instead of developing a head and a tail, a Drosophila embryo develops two tails. This is most likely due to _____. (Concept 21.3E-Book) [Hint]

 apoptosis
 a mutation in an operon
 a failure involving post-transcriptional modification of mRNA
 a mutation in a maternal effect gene
 destruction of the RNA polymerase molecules responsible for the transcription of genes that encode head-related proteins


21 .       Cytoplasmic determinants encoded by _____ genes are present in unfertilized Drosophila eggs. (Concept 21.3E-Book) [Hint]

 homeotic
 segment-polarity
 segmentation
 pair-rule
 egg-polarity


22 .       Which of the following sequences of gene expression is correct for a developing fruit fly? (Concept 21.3E-Book) [Hint]

 egg-polarity genes, segmentation genes, homeotic genes
 homeotic genes, egg-polarity genes, segmentation genes
 segmentation genes, maternal effect genes, egg-polarity genes
 segmentation genes, egg-polarity genes, homeotic genes
 egg-polarity genes, homeotic genes, segmentation genes


23 .       A homeotic gene does which of the following? (Concept 21.3E-Book) [Hint]

 It serves as the ultimate control for the establishment of developmental polarity.
 It regulates the expression of groups of other genes during development.
 It represses the histone proteins that package eukaryotic DNA.
 It helps splice mRNA after transcription.
 It inactivates one of the X chromosomes in a female mammal.


24 .       When out for a walk with a friend you come across a grasshopper whose thorax bears two pairs of legs and one pair of antennae (a grasshopper usually has antennae on its head). Displaying your considerable knowledge of animal development, you explain to your friend that a possible cause of this unusual situation would be a mutation in a _____ gene. (Concept 21.3E-Book) [Hint]

 ced
 segmentation
 pair-rule
 homeotic
 egg-polarity


25 .       A complete cell lineage diagram, which shows the fate of all the somatic cells of an adult organism, has been developed for _____. (Concept 21.3E-Book) [Hint]

 D. rerio
 H. sapiens
 C. elegans
 D. melanogaster
 M. musculus


26 .       During development, which of the following is the first thing that happens when an inducer acts on target cells? (Concept 21.3E-Book) [Hint]

 A transcription factor acts on the DNA.
 The inducer binds to the DNA.
 A new protein is made in the target cell.
 A specific gene is transcribed.
 The inducer binds to a receptor.


27 .       If the anchor cell is destroyed, C. elegans will fail to develop a(n) _____. (Concept 21.3E-Book) [Hint]

 intestine
 vulva
 dorsal-ventral axis
 nervous system
 anterior-posterior axis


28 .       In C. elegans the gene that initiates the cascade that results in apoptosis is the _____ gene. (Concept 21.3E-Book) [Hint]

 fasciated
 bicoid
 homeobox
 ced-9
 myoD


29 .       If not for apoptosis, you would _____. (Concept 21.3E-Book) [Hint]

 be immortal
 have webbed fingers and toes
 be unable to avoid getting cancer
 never get cancer
 have too few cells


30 .       Which of the following genes does not encode a protein that plays a role in animal development? (Concept 21.3E-Book) [Hint]

 bicoid
 maternal effect genes
 fasciated
 ced-3
 All of these genes are involved in animal development.


31 .       In tomatoes, the fasciated gene determines the _____. (Concept 21.3E-Book) [Hint]

 anterior-posterior axis
 death of a cell
 number of organs a flower will have
 organ that develops from a particular region of meristem
 expression of cytoplasmic determinants


32 .       In plants, the structures that develop from meristems depend on the expression of _____ genes. (Concept 21.3E-Book) [Hint]

 organ-identity
 egg-polarity
 homeobox
 chimera
 L3


33 .       The highly conserved sequence element present within homeotic genes is called the _____. (Concept 21.4E-Book) [Hint]

 homeobox
 bicoid
 ced-3
 morphogen
 TATA box


34 .       The similarity of the homeobox in many different kinds of organisms is evidence _____. (Concept 21.4E-Book) [Hint]

 of convergent evolution
 of analogy
 that it is not responsive to natural selection
 of its recent origin
 of the common ancestry of different life-forms


35 .       The development of plants is similar to the development of animals in that both depend on _____; it is different in that animals are more dependent on _____. (Concept 21.4E-Book) [Hint]

 cell signaling ... cell movement
 transcriptional regulation ... cell signaling
 cytoplasmic determinants ... induction
 cell signaling ... transcriptional regulation
 differing planes of cytokinesis ... homeotic genes







©2005 Pearson Education, Inc., publishing as Benjamin Cummings